When a meteor full of space gunk transforms Susan Murphy (Reese Witherspoon) into a giant, the government renames her Ginormica and confines her to a secret compound with other monsters, like bug-headed Dr. Cockroach (Hugh Laurie) . When an extraterrestrial robot lands on Earth and begins a rampage, Gen. W.R. Monger persuades the president to send Ginormica and her fellow monsters to battle the machine and save the planet.
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